Heart Matters: An Irvine Company Designs a Heart Valve that Saves a World War II Veteran

Two Southern California gentlemen born decades apart. One is Michael A. Mussallem, Chairman of the Board and CEO of one of Irvine’s largest companies, Edwards Lifesciences. The other is Dr. Lester I. Tenney, a World War II veteran, survivor of the infamous Bataan Death March and former prisoner of war of the Japanese military. Their paths would cross seven years ago when Lester was told that he had only one year to live.

Michael A. Mussallem (Photo courtesy of Edwards Lifesciences) and Dr. Lester Tenney
Michael A. Mussallem (Photo courtesy of Edwards Lifesciences) and Dr. Lester Tenney

Edwards Lifesciences in Irvine

Edwards Lifesciences (NYSE: EW) is a medical technology company headquartered in Irvine specializing in heart valves and monitoring devices for the circulatory system. Edwards takes its namesake from engineer Miles “Lowell” Edwards who became interested in healing the human heart due to his own childhood experience with rheumatic fever which can cause scaring of heart valves and heart failure. 1)http://www.edwards.com/aboutus/OurHistory

We have the privilege on a regular basis to meet many remarkable patients whose lives have been saved and improved as a result of their treatment with one of our therapies, and it is our single greatest motivation and inspiration at Edwards. – Mike Mussallem, CEO of Edwards Lifesciences

He teamed up with Dr. Albert Starr and developed the first known successful mechanical heart valve ever implanted into a human patient. Edwards founded Edwards Laboratories in Santa Ana, California. Following restructuring, Edwards Lifesciences spun off and became an independent and publicly traded company in 2000. Today, one of the company’s most notable technological innovations is their transcatheter aortic heart valve.  2)http://www.edwards.com/aboutus/OurHistory

Lester Tenney, a WWII Veteran Receives Edwards’ Transcatheter Aortic Heart Valve

During World War II, Lester served in the US Army in the 192nd Tank Battalion. In the spring of 1942, following what would be one of the largest surrenders in US military history; Lester was captured in the Philippines by the Japanese Imperial Army. He was forced to walk the Bataan Death March and put to work as a slave laborer until he was liberated in 1945.

Lester Tenney in Fort Knox in June of 1941 (Photo courtesy of Lester Tenney)
Lester Tenney in Fort Knox in June of 1941 (Photo courtesy of Lester Tenney)

In his 1995 memoir, My Hitch in Hell, Lester recounts his harrowing story of surviving the Bataan Death March and then being sent to Japan to work as a slave laborer for a Mitsui coal mine. More recently, he wrote The Courage to Remember, a book on how he was able to overcome his post traumatic stress syndrome from his wartime experiences. In his book, he says that he found peace by letting go of bitterness and hatred. He concludes that the act of forgiving others was a gift he gave to himself. “Because of forgiveness, I am a prisoner no more.” wrote Lester.

In 2009, decades after his liberation, Lester was invited to lead a delegation of former POWs to Japan to receive a long-awaited apology from the Japanese government for the inhumane treatment they suffered during World War II. But at 90 years old, Lester’s health was failing.

Lester’s cardiologist told him that he needed a new aortic heart valve but because of his age, he was not a candidate for invasive open heart surgery. He was told if they did nothing, he would have maybe one year to live. Unable to accept this prognosis, Lester began researching less invasive treatment options.

I feel my life was saved by entering the Heart Valve Trial of Edwards Lifesciences. I was very lucky to have found them when I did. Thank you Edwards for these seven extra years. – Lester Tenney

“I believe strongly that we must be in charge of our own body. We can’t go through life giving that responsibility to someone else just because he or she is a medical doctor. We must be a part of the team that takes care of us. In fact, we are the most important piece of this puzzle.” says Lester.

He found out that Scripps, a hospital near his home in San Diego, was conducting a new clinical trial of the Edwards transcatheter aortic heart valve replacement (“TAVR”) treatment. Using this method, a patient is able to receive a new heart valve via a catheter instead of by open heart surgery. In the spring of 2010, Lester became a member of the clinical trial and received an Edwards heart valve. Today, the TAVR treatment has become a widely available option for patients needing an aortic heart valve replacement.

Just months after this life saving procedure, Lester traveled to Japan and received an official apology from then Japanese Foreign Minister Katsuya Okada. Looking back, Lester says “I picked up seven years that I never would have had.”

Patient and Innovation Focused Culture at Edwards

What does it take for a company to achieve breakthrough therapies for patients such as the TAVR? CEO Mike Mussallem says you have to accept the very real risk of failure on the path to success.

You once said, “I think if you really want to be an innovator in this world, you need to have the willingness to reach and the willingness to fail.” How has this philosophy helped Edwards reach for new breakthroughs in medical technology?

Mike: The recognition that we need to reach and be willing to fail comes from our patient- and innovation-focused culture at Edwards. We became an independent company 16 years ago because we wanted to be able to innovate more quickly and effectively for patients, and invest more resources in research and development.

Edwards Lifesciences headquarters in Irvine, California(Photo courtesy of Edwards Lifesciences)
Edwards Lifesciences headquarters in Irvine, California (Photo courtesy of Edwards Lifesciences)

Whenever we do bold things and pursue truly breakthrough therapies for patients, the opportunity for failure is real and we need to be able to tolerate failure. Only in failure can we learn and find the answers to the big healthcare challenges that we pursue.  We embrace a “shots on goal” mentality as we innovate, which means that we’re going to have some misses on our way to success. We know that when we keep our focus on patients, and partner with clinicians to address the unmet needs of their patients, we will drive meaningful change together.

Setting aside the medical technology aspect of Edwards for a moment, when people think about the word “heart,” it’s a very symbolic word. Expressions like “heart’s content,” “heart and soul” and “young at heart” come to mind. What does this mean to you and to Edwards to specialize in healing the human heart?

Mike: Our work at Edwards is personal. We have the opportunity to touch the lives of individuals all over the world with the work that we do. This means that people like Lester have the chance to fulfill a lifelong goal.

Lester speaks at Edwards headquarters in Irvine on Patient Day in 2015 (Photo courtesy of Edwards Lifesciences)
Lester speaks at Edwards headquarters in Irvine on Patient Day in 2015 (Photo courtesy of Edwards Lifesciences)

It is an honor and a great responsibility to create, hand-assemble and provide heart valves to people all around the world to save and sustain lives. We spend every day looking for answers to how we can better treat patients with heart valve disease and address unmet patient needs. Our 13,000 global employees are focused on patients first, and we come to work every day knowing that helping patients is our life’s work, and life is now.

It was Edwards’ transcatheter aortic heart valve technology that enabled Lester to travel to Japan to receive a long-awaited apology. You once said, “[o]ur work is personal, and it impacts people individually.” To ask the opposite question, how do patients like Lester impact you in a personal way?

Mike: Lester is an amazing person and an inspiration to me personally, and to many at Edwards. I’ve had the honor to spend time with Lester and his wife, Betty, and it is a privilege to know them. This is a man who persevered in conditions that few people ever face, and even fewer could survive. Lester had incomparable mental and physical strength – yet decades later, he found his life threatened by a heart valve disease that could be solved by new technology, if he could get access to it.

Mike visits Lester at his home (Photo courtesy of Edwards Lifesciences)
Mike visits Lester at his home (Photo courtesy of Edwards Lifesciences)

It’s humbling to know that our transcatheter aortic heart valve was able to restore his health, and enable him to travel to Japan to receive an apology for WWII veterans for the tragedies they suffered during the war.

 We have the privilege on a regular basis to meet many remarkable patients whose lives have been saved and improved as a result of their treatment with one of our therapies, and it is our single greatest motivation and inspiration at Edwards. I have photos of many of these individuals on my shelf in my office, and we have many more lining the halls of our offices at Edwards, to remind us all daily of the reason for the work we are doing.

Lester and his wife, Betty
Lester and his wife, Betty

“I feel my life was saved by entering the Heart Valve Trial of Edwards Lifesciences. I was very lucky to have found them when I did. Thank you Edwards for these seven extra years.” says Lester, a member of our greatest generation.

Editor’s note: Lester passed away on February 24, 2017 in Carlsbad, California at the age of 96.  Read his obituary on the NY Times here.

To learn more about Edwards Lifesciences, visit: www.edwards.com

Connect with Edwards on social media: Twitter | LinkedIn | YouTube


References   [ + ]

1, 2. http://www.edwards.com/aboutus/OurHistory
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Google Fiber Coming to Irvine: What this Means for Our City

Google search engine, Gmail, Google Calendar, Google Drive, Chrome, Android, Hangouts, Google Maps, Google Voice. Get ready to add one more to this list of popular Google services: GOOGLE FIBER.

Google Irvine Office
PHOTO: Google’s Irvine office located at 19510 Jamboree Rd #300, Irvine, CA 92612.

Irvine will be Orange County’s first city to have Google Fiber.

Here are some short-term and long-term changes that are headed our way:

    • Google Fiber will offer broadband speeds up to 1 gigabit or 1,000 megabits/second
    • Consumers will likely receive better service and more competitive pricing from existing Internet Service Providers due to competition from Google Fiber
    • Faster internet connection and more affordability will likely mean increased usage of Google’s services by consumers

Irvine currently has two main Internet Service Providers: Cox Communications (Cable) and AT&T U-Verse (DSL).  As of the writing of this article, Cox charges $39.99 for up to 15mbps and AT&T charges $45 for up to 18mbps. Higher connection speeds are offered by both companies: Cox has a package for $84.99 for up to 300mbps and AT&T offers $65 for up to 45mbps. (Note: rates are 1-year promo rates and regular rates are higher for all packages.) AT&T’s U-Verse with GigaPower is also available in some parts of Irvine. Packages range from approximately $80-120, depending on if you allow for tracking of your internet history and targeted banner ads.  Google Fiber packages range from $50 to $130 for internet and TV subscriptions. Small business packages range from $70 to $250.

The timing of when Google Fiber (internal name “Access”) will arrive is yet unclear. Just this week, Google announced that they are putting a hold on plans for Google Fiber in at least two Silicon Valley cities to explore cheaper alternatives for cable networks. Indeed Mountain View and Palo Alto have also had their projects delayed. Last month, Larry Page, CEO of Alphabet ordered that employees on the Google Fiber workforce be cut from 1,000 employees to 500, due to subscription numbers being lower than anticipated.

Previous Google Fiber roll out plans included an estimated 60% of cable networks and 40% aerial. With the recent acquisition of Webpass, a high-speed, fiber internet provider, it is likely Google will focus more on aerial networks using Webpass’ point-to-point wireless connection technologies as opposed to the time-consuming installation of underground fiber cables.

Google Fiber has already gone live in seven major cities all outside of California. Google Fiber is a subsidiary of Alphabet Inc., the parent company of Google. (Traded as NASDAQ: GOOGL.) Following the restructuring of the company in October of 2015, Google Fiber became part of Alphabet Inc.’s “Access and Energy” business unit.

Some analysts have opined that Google’s intention all along was merely to encourage other ISPs to improve their service and lower their rates so that consumers would have more accessibility to Google products. These analysts suggest Google has no real interest in competing in the ISP market. “It’s not clear (Google was) ever all that serious about doing this at any real size.” said Craig Moffett of MoffettNathanson Research.

Whether Google intends to compete in the ISP market or simply encourage traditional ISPs to build up their own networks, the effect of Google Fiber will be substantial. Roger Entner, an analyst with Recon Analytics LLC was quoted by Bloomberg as saying, “Markets that Google enters enjoy a $20-a-month drop in prices, on average.”

PHOTO: "Irvine welcomes you"
PHOTO: “Irvine welcomes you”

So what else could the arrival of Google mean for us consumers? For entertainment purposes, you’ll be able to stream Game of Thrones or the next Olympics without buffering or stuttering. Gamers will also enjoy a lag-free gaming experience.

On the business side of things, Google has announced Google Fiber packages for small businesses, which could translate to better productivity and more accessibility to higher levels of video conferencing such as HD video conferencing or virtual presence meetings. Other business usages include telemedicine where doctors could simulate office visits with patients without actually meeting in person or virtual coaching sessions between a coach and an athlete or client.

More affordable internet service could also help nonprofit organizations and low-income individuals have more access to high speed internet.

Pros and cons a plenty with the arrival of the internet giant, the company whose unofficial motto is “Do no evil.” One thing is certain, with Irvine’s rapid growth in population and business, the arrival of Google Fiber will only accelerate our growth.

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200 Spectrum Center Drive: Changing the Skyline of Irvine

Irvine isn’t exactly known for high rise buildings, instead preferring low and midrises or even sprawling shopping centers like the Irvine Spectrum. But at 21 stories tall, the new high rises at 200 & 400 Spectrum Center Drive are changing the Irvine skyline. Standing 323 feet tall, these towers are now the tallest buildings in all of Orange County.

200 Spectrum Center Drive
200 Spectrum Center Drive

Both buildings are expected to receive Leadership in Energy & Environmental Design (LEED) Gold Certification from the US Green Building Council based on the buildings’ environmental impact and human health benefits. The towers were developed by Irvine Company and designed by the architecture firm Pei Cobb Freed who designed California’s tallest skyscraper, the U.S. Bank tower in downtown Los Angeles.

The first tenants at 200 Spectrum include Mazda’s North American Operations, shared-workspace group WeWork and the gaming communications company Curse Inc. *Update: since the writing of this article, Curse was acquired by Twitch, a live streaming gaming company that was recently acquired by Amazon.com.1)http://www.ocregister.com/articles/curse-726133-twitch-irvine.html The sister tower at 400 Spectrum is expected to open in 2017.

200 Spectrum Center Drive Building
200 Spectrum Center Drive Building

As can be expected, these Irvine Company properties feature hotel-like amenities such as casual work spaces, complimentary WiFi, a fitness center and outdoor meeting areas.

This is an exciting time of growth in Irvine, we look forward to seeing what other tenants will occupy these glass towers.

References   [ + ]

1. http://www.ocregister.com/articles/curse-726133-twitch-irvine.html
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